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Brain Health
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If you are interested in participating, or you would like to learn more about the study, please contact Geoff Coombs (coombg1@mcmaster.ca, 613-558-9637).
Acute Oral Ketone Monoester Supplementation
Overview: The impact of acute oral ketone monoester supplementation on resting-state brain connectivity in adults with memory complaints study will be a randomized double-blind placebo-controlled crossover design with approximately 30 participants. It will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.
| Study Type: | Interventional |
| Overview & Objectives: | People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. Interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. Exogenous ketone supplements have been shown rapidly improves brain network function in young adults. Further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. Whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown.
This study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints. The primary objectives are to assess: 1) brain network connectivity; and 2) cerebral blood flow. The secondary objectives are to assess: 1) working memory; 2)executive function; and 3) attention and working memory. |
| Methods: |
The study has 3 testing visits: 1 familiarization and screening visit, and 2 experimental visits. The first visit will be ~1 hour, and the subsequent two visits will be ~1.5 hours each. The total expected time commitment is 4-5 hours. |
